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ClinicalTrials.gov; 28/01/2024; TrialID: NCT06245538
Clinical Trial Register
| ICTRP | ID: ictrp-NCT06245538
ABSTRACT
Condition:
Healthy Adults;Adults With Stress-related SymptomsIntervention:
Behavioral: Seated rest;Behavioral: Exercise at moderate intensity;Behavioral: Exercise at vigorous intensityPrimary outcome:
Changes in cerebral blood flow in prefrontal cortexCriteria:
Inclusion Criteria:
For participants both with and without stress-related symptoms:
- Age: 20-40 years
- Absence of contraindications to physical exercise
- Do not participate in any other study
For participants with stress-related symptoms:
• Total score on the self-assessment scale 4-factor Shirom-Melamed Burnout Measure-19
greater than or equal to 2.95 but lower than 4.00
For healthy controls:
• Total score on the self-assessment scale 4-factor SMBM-19 lower than or equal to 2.21
Exclusion Criteria:
For participants both with and without stress-related symptoms:
- Medical contraindication to catheterization of the antecubital vein and blood sampling
- Dementia
- Alcohol abuse
- Smoking
- Chronic medication that is considered to affect study outcomes
- Chronic disease/syndrome such as migraine, fibromyalgia, chronic fatigue syndrome,
bipolar syndrome, high blood pressure, cardiovascular disease, chronic obstructive
pulmonary disease (COPD) or other lung disease
- Post-COVID
- Other somatic diseases, disorders, or injuries that may affect the physical ability
during physical exercise
Exclusively for healthy controls:
• Depression (HAD depression score < 8) and anxiety (HAD anxiety score < 8)